MolNFT v1 · #96519 · protein
Structure of porcine cgas in complex with bound UTP
4JLZ · Uncharacterized protein: “Structure of porcine cgas in complex with bound UTP”. X-ray diffraction, 3 ligands (UTP, ZN, MG), 6 pockets (best druggability 0.81). MolNFT v1 #96519 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 4JLZ
- Type
- protein
- Length
- 718 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uncharacterized protein
- UniProt
- I3LM39
- Ligands
- UTP, ZN, MG
- Pockets
- 6 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Uncharacterized protein | protein | 363 | 45% helix, 16% strand | I3LM39 |
| B | Uncharacterized protein | protein | 355 | 45% helix, 18% strand | I3LM39 |
Ligands and binding sites
- UTP · Uridine 5'-triphosphate · ligand · 2 copies · chains A, B
- ZN · Zinc ion · metal · 2 copies · chains A, B
- MG · Magnesium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 688 | 0.81 | 0.86 | 82 | empty |
| 2 | 517 | 0.73 | 0.81 | 63 | MG, UTP |
| 3 | 198 | 0.62 | 0.83 | 35 | MG, UTP |
| 4 | 244 | 0.53 | 0.76 | 40 | empty |
| 5 | 69 | 0.40 | 0.80 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 1218 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt I3LM39
- Elsewhere: RCSB PDB 4JLZ · PDBe 4JLZ · UniProt I3LM39
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