MolNFT v1 · #9650 · protein
Structure of conserved protein MTH1747 of unknown function reveals structural similarity with 3-hydroxyacid dehydrogenases
1I36 · Conserved hypothetical protein MTH1747: “Structure of conserved protein MTH1747 of unknown function reveals structural similarity with 3-hydroxyacid…”. X-ray diffraction, 1 ligand (NAP), 7 pockets (best druggability 0.69). MolNFT v1…
- PDB
- 1I36
- Type
- protein
- Length
- 516 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Conserved hypothetical protein MTH1747
- UniProt
- O27779
- Ligands
- NAP
- Pockets
- 7 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 58% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Conserved hypothetical protein MTH1747 | protein | 258 | 58% helix, 14% strand | O27779 |
Ligands and binding sites
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 644 | 0.69 | 0.78 | 65 | NAP |
| 2 | 509 | 0.64 | 0.77 | 51 | NAP |
| 3 | 57 | 0.50 | 0.86 | 15 | empty |
| 4 | 87 | 0.43 | 0.80 | 19 | empty |
| 5 | 87 | 0.40 | 0.78 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 2402 Ų buried · 21 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 1I36 · Structure of Conserved Protein MTH1747 of Unknown Function Reveals Structural Similarity… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O27779
- Elsewhere: RCSB PDB 1I36 · PDBe 1I36 · UniProt O27779
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