MolNFT v1 · #96432 · protein
Crystal structure of the D1 domain from human nectin-4 extracellular fragment [psi-nysgrc-005624]
4JJH · Poliovirus receptor-related protein 4: “Crystal structure of the D1 domain from human nectin-4 extracellular fragment [psi-nysgrc-005624]”. X-ray diffraction, 1 pocket (best druggability 0.33). MolNFT v1 #96432 on GenesisL1: 3D…
- PDB
- 4JJH
- Type
- protein
- Length
- 223 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Poliovirus receptor-related protein 4
- UniProt
- Q96NY8
- Pockets
- 1 · best druggability 0.33
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Poliovirus receptor-related protein 4 | protein | 111 | 5% helix, 49% strand | Q96NY8 |
| B | Poliovirus receptor-related protein 4 | protein | 112 | 5% helix, 50% strand | Q96NY8 |
Ligands and binding sites
- EDO · 1,2-ethanediol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 70 | 0.33 | 0.76 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 466 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96NY8
- Elsewhere: RCSB PDB 4JJH · PDBe 4JJH · UniProt Q96NY8
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