MolNFT v1 · #96195 · protein
CLPP1 from listeria monocytogenes
4JCQ · ATP-dependent clp protease proteolytic subunit: “CLPP1 from listeria monocytogenes”. X-ray diffraction, 20 pockets (best druggability 0.63). MolNFT v1 #96195 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4JCQ
- Type
- protein
- Length
- 4,760 residues
- Chains
- 28
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-dependent clp protease proteolytic subunit
- EC
- 3.4.21.92
- UniProt
- Q8Y7Y1
- Pockets
- 20 · best druggability 0.63
Structure
x-ray diffraction · 1 distinct chain · 49% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b | ATP-dependent clp protease proteolytic subunit (EC 3.4.21.92) | protein | 170 | 49% helix, 22% strand | Q8Y7Y1 |
Pockets
20 pockets found on a 1 Å grid, 18 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 355 | 0.63 | 0.79 | 28 | empty |
| 2 | 328 | 0.57 | 0.76 | 32 | empty |
| 3 | 221 | 0.55 | 0.78 | 46 | empty |
| 4 | 219 | 0.54 | 0.78 | 34 | empty |
| 5 | 302 | 0.54 | 0.75 | 51 | empty |
Interfaces
59 interfaces between chains.
- S–T · 1368 Ų buried · 21 hydrogen bonds · protein-protein
- E–F · 1365 Ų buried · 22 hydrogen bonds · protein-protein
- C–D · 1361 Ų buried · 22 hydrogen bonds · protein-protein
- B–C · 1357 Ų buried · 24 hydrogen bonds · protein-protein
- R–S · 1357 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 4JCQ · ClpP1 from Listeria monocytogenes · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8Y7Y1
- Elsewhere: RCSB PDB 4JCQ · PDBe 4JCQ · UniProt Q8Y7Y1
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