MolNFT v1 · #96070 · protein

Crystal structure of MYCP1 from the esx-1 type VII secretion system

4J94 · Membrane-anchored mycosin MYCP1: “Crystal structure of MYCP1 from the esx-1 type VII secretion system”. X-ray diffraction, 4 pockets (best druggability 0.67). MolNFT v1 #96070 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 4J94
Type: protein
Length: 380 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Membrane-anchored mycosin MYCP1
EC: 3.4.21.62
UniProt: A0QNL1
Pockets: 4 · best druggability 0.67

Structure

x-ray diffraction · 1 distinct chain · 24% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Membrane-anchored mycosin MYCP1 (EC 3.4.21.62)	protein	380	24% helix, 19% strand	A0QNL1

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	526	0.67	0.78	61	empty
2	182	0.50	0.77	33	empty
3	57	0.34	0.77	19	empty
4	53	0.26	0.73	13	empty

Modifications

Observed in the structure: 5 modified, 1 disulfide (engineered, disulfide).

Compared structures

4J94 · Crystal structure of MycP1 from the ESX-1 type VII secretion system · the same entry in another collection · chain A against A, TM-score 1.00
A0QNL1 · AlphaFold monomer V2.0 prediction for mycosin-1 (A0QNL1) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0QNL1
Elsewhere: RCSB PDB 4J94 · PDBe 4J94 · UniProt A0QNL1

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