MolNFT v1 · #9598 · protein

Structure of melanoma inhibitory activity protein: a member of a new family of secreted proteins

1I1J · Melanoma derived growth regulatory protein: “Structure of melanoma inhibitory activity protein: a member of a new family of secreted proteins”. X-ray diffraction, 2 pockets (best druggability 0.47). MolNFT v1 #9598 on GenesisL1: 3D…

PDB: 1I1J
Type: protein
Length: 210 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Melanoma derived growth regulatory protein
UniProt: Q16674
Pockets: 2 · best druggability 0.47

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Melanoma derived growth regulatory protein	protein	106	6% helix, 40% strand	Q16674
B	Melanoma derived growth regulatory protein	protein	104	9% helix, 40% strand	Q16674

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	88	0.47	0.81	19	empty
2	122	0.46	0.78	21	empty

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

1I1J · Structure of melanoma inhibitory activity protein: a member of a new family of secreted… · the same entry in another collection · chain A against A, TM-score 1.00
Q16674 · AlphaFold monomer V2.0 prediction for melanoma-derived growth regulatory protein (Q16674) · a predicted model of the same protein · chain B against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q16674
Elsewhere: RCSB PDB 1I1J · PDBe 1I1J · UniProt Q16674

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