MolNFT v1 · #95924 · protein

Pentamer sftsvn

4J4U · Nucleocapsid protein: “Pentamer sftsvn”. X-ray diffraction, 12 pockets (best druggability 0.75). MolNFT v1 #95924 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4J4U
Type: protein
Length: 1,226 residues
Chains: 5
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nucleocapsid protein
UniProt: I6WJ72
Pockets: 12 · best druggability 0.75

Structure

x-ray diffraction · 2 distinct chains · 65% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nucleocapsid protein	protein	246	63% helix, 2% strand	I6WJ72
B, C, D, E	Nucleocapsid protein	protein	245	67% helix, 1% strand	I6WJ72

Pockets

12 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	437	0.75	0.84	73	empty
2	258	0.72	0.86	47	empty
3	275	0.72	0.86	49	empty
4	254	0.71	0.86	48	empty
5	103	0.61	0.87	22	empty

Interfaces

5 interfaces between chains.

A–B · 1825 Å² buried · 14 hydrogen bonds · protein-protein
B–C · 1801 Å² buried · 14 hydrogen bonds · protein-protein
A–E · 1732 Å² buried · 13 hydrogen bonds · protein-protein
C–D · 1730 Å² buried · 15 hydrogen bonds · protein-protein
D–E · 1711 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

4J4U · Pentamer SFTSVN · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt I6WJ72
Elsewhere: RCSB PDB 4J4U · PDBe 4J4U · UniProt I6WJ72

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