MolNFT v1 · #95852 · protein
Middle domain of influenza a virus RNA-dependent polymerase PB2
4J2R · Polymerase basic protein 2: “Middle domain of influenza a virus RNA-dependent polymerase PB2”. X-ray diffraction, 3 pockets (best druggability 0.43). MolNFT v1 #95852 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4J2R
- Type
- protein
- Length
- 326 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Polymerase basic protein 2
- UniProt
- P03428
- Pockets
- 3 · best druggability 0.43
Structure
x-ray diffraction · 1 distinct chain · 24% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Polymerase basic protein 2 | protein | 163 | 24% helix, 37% strand | P03428 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 87 | 0.43 | 0.79 | 21 | empty |
| 2 | 104 | 0.41 | 0.76 | 21 | empty |
| 3 | 111 | 0.37 | 0.74 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 540 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 4J2R · Middle domain of influenza A virus RNA-dependent polymerase PB2 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03428
- Elsewhere: RCSB PDB 4J2R · PDBe 4J2R · UniProt P03428
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