MolNFT v1 · #95770 · protein
Crystal structure of 3-hydroxyacyl-CoA dehydrogenase from caenorhadbitis elegans in P212121 space group
4J0F · Probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1: “Crystal structure of 3-hydroxyacyl-CoA dehydrogenase from caenorhadbitis elegans in P212121 space group”. X-ray diffraction, 6 pockets (best druggability 0.67). MolNFT v1 #95770 on…
- PDB
- 4J0F
- Type
- protein
- Length
- 572 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1
- EC
- 1.1.1.35
- UniProt
- P34439
- Pockets
- 6 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 51% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1 (EC 1.1.1.35) | protein | 287 | 51% helix, 15% strand | P34439 |
| B | Probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1 (EC 1.1.1.35) | protein | 285 | 50% helix, 15% strand | P34439 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 391 | 0.67 | 0.80 | 39 | empty |
| 2 | 419 | 0.66 | 0.79 | 40 | empty |
| 3 | 68 | 0.41 | 0.80 | 14 | empty |
| 4 | 64 | 0.40 | 0.80 | 16 | empty |
| 5 | 92 | 0.38 | 0.76 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1692 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 4J0F · Crystal structure of 3-hydroxyacyl-CoA dehydrogenase from Caenorhadbitis elegans in… · the same entry in another collection · chain A against A, TM-score 1.00
- P34439 · AlphaFold monomer V2.0 prediction for probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P34439
- Elsewhere: RCSB PDB 4J0F · PDBe 4J0F · UniProt P34439
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