MolNFT v1 · #95675 · protein

Structure of DNA-binding domain of the response regulator saer from staphylococcus epidermidis

4IXA: “Structure of DNA-binding domain of the response regulator saer from staphylococcus epidermidis”. X-ray diffraction, 2 pockets (best druggability 0.47). MolNFT v1 #95675 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4IXA
Type: protein
Length: 196 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Response regulator saer
UniProt: Q8CQ17
Pockets: 2 · best druggability 0.47

Structure

x-ray diffraction · 2 distinct chains · 36% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Response regulator saer	protein	102	33% helix, 27% strand	Q8CQ17
B	Response regulator saer	protein	94	38% helix, 30% strand	Q8CQ17

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	104	0.47	0.80	16	empty
2	172	0.45	0.75	29	empty

Interfaces

1 interface between chains.

A–B · 347 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

4IXA · Structure of DNA-binding domain of the response regulator SaeR from Staphylococcus… · the same entry in another collection · chain A against A, TM-score 1.00
Q8CQ17 · AlphaFold monomer V2.0 prediction for response regulator saer (Q8CQ17) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8CQ17
Elsewhere: RCSB PDB 4IXA · PDBe 4IXA · UniProt Q8CQ17

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