MolNFT v1 · #95644 · protein

Novel fold of FLIC/FLIS fusion protein

4IWB · Flic, flis chimera: “Novel fold of FLIC/FLIS fusion protein”. X-ray diffraction, 3 pockets (best druggability 0.61). MolNFT v1 #95644 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4IWB
Type: protein
Length: 321 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Flic, flis chimera
UniProt: O67803, O67806
Pockets: 3 · best druggability 0.61

Structure

x-ray diffraction · 2 distinct chains · 82% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Flic, flis chimera	protein	165	82% helix, 0% strand	O67803, O67806
B	Flic, flis chimera	protein	156	81% helix, 0% strand	O67803, O67806

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	249	0.61	0.80	28	empty
2	79	0.34	0.74	16	empty
3	54	0.29	0.75	16	empty

Interfaces

1 interface between chains.

A–B · 552 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

4IWB · Novel Fold of FliC/FliS Fusion Protein · the same entry in another collection · chain A against A, TM-score 1.00
O67803 · AlphaFold monomer V2.0 prediction for flagellin (O67803) · a predicted model of the same protein · chain B against A, TM-score 0.52

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O67803
Every structure of UniProt O67806
Elsewhere: RCSB PDB 4IWB · PDBe 4IWB · UniProt O67803 · UniProt O67806

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