MolNFT v1 · #9560 · protein

Crystal structure of creatine kinase from human muscle

1I0E · Creatine KINASE,M chain: “Crystal structure of creatine kinase from human muscle”. X-ray diffraction, 8 pockets (best druggability 0.61). MolNFT v1 #9560 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1I0E
Type: protein
Length: 1,460 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Creatine KINASE,M chain
EC: 2.7.3.2
UniProt: P06732
Pockets: 8 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 33% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Creatine KINASE,M chain (EC 2.7.3.2)	protein	365	33% helix, 16% strand	P06732

Pockets

8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	330	0.61	0.78	46	empty
2	285	0.61	0.79	37	empty
3	267	0.60	0.80	40	empty
4	320	0.60	0.78	47	empty
5	156	0.45	0.76	21	empty

Compared structures

1I0E · Crystal structure of creatine kinase from human muscle · the same entry in another collection · chain A against A, TM-score 1.00
P06732 · AlphaFold monomer V2.0 prediction for creatine kinase M-type (P06732) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P06732
Elsewhere: RCSB PDB 1I0E · PDBe 1I0E · UniProt P06732

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