MolNFT v1 · #9558 · protein

EPS8 SH3 closed monomer

1I0C · Epidermal growth factor receptor kinase substrate EPS8: “EPS8 SH3 closed monomer”. X-ray diffraction, 1 pocket (best druggability 0.49). MolNFT v1 #9558 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1I0C
Type: protein
Length: 117 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Epidermal growth factor receptor kinase substrate EPS8
UniProt: Q08509
Pockets: 1 · best druggability 0.49

Structure

x-ray diffraction · 2 distinct chains · 5% helix, 48% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Epidermal growth factor receptor kinase substrate EPS8	protein	59	5% helix, 49% strand	Q08509
B	Epidermal growth factor receptor kinase substrate EPS8	protein	58	5% helix, 47% strand	Q08509

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	144	0.49	0.79	21	empty

Interfaces

1 interface between chains.

A–B · 576 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

1I0C · EPS8 SH3 closed monomer · the same entry in another collection · chain A against A, TM-score 1.00
Q08509 · AlphaFold monomer V2.0 prediction for epidermal growth factor receptor kinase substrate 8… · a predicted model of the same protein · chain B against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q08509
Elsewhere: RCSB PDB 1I0C · PDBe 1I0C · UniProt Q08509

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