MolNFT v1 · #95577 · protein

Crystal structure of a membrane transporter

4IU9 · Nitrite extrusion protein 2: “Crystal structure of a membrane transporter”. X-ray diffraction, 5 pockets (best druggability 0.66). MolNFT v1 #95577 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4IU9
Type: protein
Length: 823 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nitrite extrusion protein 2
UniProt: P37758
Pockets: 5 · best druggability 0.66

Structure

x-ray diffraction · 2 distinct chains · 69% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Nitrite extrusion protein 2	protein	427	71% helix, 1% strand	P37758
A	Nitrite extrusion protein 2	protein	396	67% helix, 2% strand	P37758

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	505	0.66	0.77	46	empty
2	152	0.48	0.77	23	empty
3	62	0.48	0.84	13	empty
4	84	0.41	0.78	17	empty
5	57	0.33	0.77	18	empty

Compared structures

4IU9 · Crystal structure of a membrane transporter · the same entry in another collection · chain A against A, TM-score 1.00
P37758 · AlphaFold monomer V2.0 prediction for NITRATE/NITRITE transporter naru (P37758) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P37758
Elsewhere: RCSB PDB 4IU9 · PDBe 4IU9 · UniProt P37758

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