MolNFT v1 · #95527 · protein

Crystal structure of the Fab fragment of 1C2, a monoclonal antibody specific for poly-glutamine

4ISV · 1C2 Fab light chain: “Crystal structure of the Fab fragment of 1C2, a monoclonal antibody specific for poly-glutamine”. X-ray diffraction, 5 pockets (best druggability 0.65). MolNFT v1 #95527 on GenesisL1: 3D structure, binding…

PDB: 4ISV
Type: protein
Length: 429 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 1C2 Fab light chain; 1C2 Fab heavy chain
Pockets: 5 · best druggability 0.65

Structure

x-ray diffraction · 2 distinct chains · 9% helix, 56% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	1C2 Fab light chain	protein	217	7% helix, 57% strand	—
B	1C2 Fab heavy chain	protein	212	10% helix, 54% strand	—

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	622	0.65	0.75	59	empty
2	80	0.33	0.75	20	empty
3	75	0.32	0.74	17	empty
4	70	0.28	0.72	16	empty
5	56	0.27	0.73	14	empty

Interfaces

1 interface between chains.

A–B · 1792 Å² buried · 19 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

4ISV · Crystal structure of the Fab FRAGMENT OF 1C2, A MONOCLONAL ANTIBODY SPECIFIC FOR… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4ISV · PDBe 4ISV

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.