MolNFT v1 · #95441 · protein
Crystal structure of methyionyl-tRNA formyltransferase from bacillus anthracis
4IQF · Methionyl-tRNA formyltransferase: “Crystal structure of methyionyl-tRNA formyltransferase from bacillus anthracis”. X-ray diffraction, 1 ligand (SO4), 14 pockets (best druggability 0.73). MolNFT v1 #95441 on GenesisL1: 3D structure…
- PDB
- 4IQF
- Type
- protein
- Length
- 1,258 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Methionyl-tRNA formyltransferase
- EC
- 2.1.2.9
- UniProt
- Q81WH2
- Ligands
- SO4
- Pockets
- 14 · best druggability 0.73
Structure
x-ray diffraction · 3 distinct chains · 27% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Methionyl-tRNA formyltransferase (EC 2.1.2.9) | protein | 314 | 28% helix, 27% strand | Q81WH2 |
| B | Methionyl-tRNA formyltransferase (EC 2.1.2.9) | protein | 314 | 26% helix, 27% strand | Q81WH2 |
| C, D | Methionyl-tRNA formyltransferase (EC 2.1.2.9) | protein | 315 | 27% helix, 28% strand | Q81WH2 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 4 copies · chains A, B, D
- GOL · Glycerol · additive · 4 copies · chains A, B, C, D
- PG5 · 1-methoxy-2-[2-(2-methoxy-ethoxy]-ethane · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
14 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 710 | 0.73 | 0.79 | 66 | GOL |
| 2 | 563 | 0.72 | 0.80 | 61 | GOL |
| 3 | 349 | 0.63 | 0.78 | 44 | GOL |
| 4 | 356 | 0.62 | 0.78 | 40 | GOL |
| 5 | 201 | 0.54 | 0.79 | 30 | empty |
Interfaces
4 interfaces between chains.
- A–D · 553 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 548 Ų buried · 6 hydrogen bonds · protein-protein
- B–D · 516 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 50 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 24 modified (engineered).
Compared structures
- 4IQF · Crystal Structure of Methyionyl-tRNA Formyltransferase from Bacillus anthracis · the same entry in another collection · chain D against D, TM-score 1.00
- Q81WH2 · AlphaFold monomer V2.0 prediction for methionyl-tRNA formyltransferase (Q81WH2) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q81WH2
- Elsewhere: RCSB PDB 4IQF · PDBe 4IQF · UniProt Q81WH2
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.