MolNFT v1 · #95431 · protein
Structure of a 16 nm protein cage designed by fusing symmetric oligomeric domains, triple mutant, P21212 form
4IQ4 · Non-haem bromoperoxidase bpo-A2, matrix protein 1: “Structure of a 16 nm protein cage designed by fusing symmetric oligomeric domains, triple mutant, P21212 form”. X-ray diffraction, 20 pockets (best druggability 0.85). MolNFT v1…
- PDB
- 4IQ4
- Type
- protein
- Length
- 2,640 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Non-haem bromoperoxidase bpo-A2, matrix protein 1
- EC
- 1.11.1.-
- UniProt
- P29715, P03485
- Pockets
- 20 · best druggability 0.85
Structure
x-ray diffraction · 1 distinct chain · 54% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | Non-haem bromoperoxidase bpo-A2, matrix protein 1 (EC 1.11.1.-) | protein | 440 | 54% helix, 13% strand | P29715, P03485 |
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1118 | 0.85 | 0.86 | 115 | empty |
| 2 | 1091 | 0.85 | 0.86 | 103 | empty |
| 3 | 714 | 0.69 | 0.77 | 56 | empty |
| 4 | 372 | 0.65 | 0.79 | 34 | empty |
| 5 | 365 | 0.63 | 0.78 | 38 | empty |
Interfaces
9 interfaces between chains.
- A–C · 919 Ų buried · 16 hydrogen bonds · protein-protein
- D–E · 911 Ų buried · 15 hydrogen bonds · protein-protein
- E–F · 903 Ų buried · 16 hydrogen bonds · protein-protein
- D–F · 892 Ų buried · 16 hydrogen bonds · protein-protein
- B–C · 890 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 4IQ4 · Structure of a 16 nm protein cage designed by fusing symmetric oligomeric domains, triple… · the same entry in another collection · chain E against E, TM-score 1.00
- P29715 · AlphaFold monomer V2.0 prediction for non-haem bromoperoxidase bpo-A2 (P29715) · a predicted model of the same protein · chain B against A, TM-score 0.63
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P29715
- Every structure of UniProt P03485
- Elsewhere: RCSB PDB 4IQ4 · PDBe 4IQ4 · UniProt P29715 · UniProt P03485
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.