MolNFT v1 · #9542 · protein
Domain swing upon his to ala mutation in nitrite reductase of pseudomonas aeruginosa
1HZV: “Domain swing upon his to ala mutation in nitrite reductase of pseudomonas aeruginosa”. X-ray diffraction, 3 ligands (HEC, DHE, NO), 2 pockets (best druggability 0.79). MolNFT v1 #9542 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1HZV
- Type
- protein
- Length
- 514 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nitrite reductase
- EC
- 1.9.3.2
- UniProt
- P24474
- Ligands
- HEC, DHE, NO
- Pockets
- 2 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 13% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nitrite reductase (EC 1.9.3.2) | protein | 514 | 13% helix, 38% strand | P24474 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 636 | 0.79 | 0.84 | 67 | DHE, NO |
| 2 | 487 | 0.68 | 0.79 | 40 | HEC |
Modifications
Observed in the structure: 2 cofactor (heme c attachment).
Compared structures
- 1HZV · Domain swing upon his to ala mutation in nitrite reductase of pseudomonas aeruginosa · the same entry in another collection · chain A against A, TM-score 1.00
- P24474 · AlphaFold monomer V2.0 prediction for nitrite reductase (P24474) · a predicted model of the same protein · chain A against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P24474
- Elsewhere: RCSB PDB 1HZV · PDBe 1HZV · UniProt P24474
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