MolNFT v1 · #95333 · protein
Crystal structure of human splicing factor DIM2/TXNL4B
4IN0 · Thioredoxin-like protein 4B: “Crystal structure of human splicing factor DIM2/TXNL4B”. X-ray diffraction, 2 ligands (GLC, FRU), 4 pockets (best druggability 0.62). MolNFT v1 #95333 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4IN0
- Type
- protein
- Length
- 282 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Thioredoxin-like protein 4B
- UniProt
- Q9NX01
- Ligands
- GLC, FRU
- Pockets
- 4 · best druggability 0.62
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Thioredoxin-like protein 4B | protein | 141 | 34% helix, 23% strand | Q9NX01 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 223 | 0.62 | 0.81 | 32 | empty |
| 2 | 100 | 0.44 | 0.79 | 22 | empty |
| 3 | 71 | 0.35 | 0.76 | 17 | empty |
| 4 | 55 | 0.26 | 0.73 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 748 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NX01
- Elsewhere: RCSB PDB 4IN0 · PDBe 4IN0 · UniProt Q9NX01
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