MolNFT v1 · #95287 · protein + RNA
CRISPR RNA processing endoribonuclease
4ILM · CRISPR-associated endoribonuclease CAS6 2: “CRISPR RNA processing endoribonuclease”. X-ray diffraction, 20 pockets (best druggability 0.78). MolNFT v1 #95287 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4ILM
- Type
- protein + RNA
- Length
- 2,353 residues
- Chains
- 16
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CRISPR-associated endoribonuclease CAS6 2; RNA…
- EC
- 3.1.-.-
- UniProt
- Q97WV8
- Pockets
- 20 · best druggability 0.78
Structure
x-ray diffraction · 8 distinct chains · 29% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | CRISPR-associated endoribonuclease CAS6 2 (EC 3.1.-.-) | protein | 279 | 30% helix, 34% strand | Q97WV8 |
| R, C, E, G, I, K, M, O | RNA (5'-R(*GP*CP*UP*AP*AP*UP*CP*UP*AP*CP*UP*AP*UP*AP*GP*A)- 3') | rna | 16 | — | — |
| B | CRISPR-associated endoribonuclease CAS6 2 (EC 3.1.-.-) | protein | 281 | 28% helix, 33% strand | Q97WV8 |
| D, H | CRISPR-associated endoribonuclease CAS6 2 (EC 3.1.-.-) | protein | 276 | 30% helix, 32% strand | Q97WV8 |
| F | CRISPR-associated endoribonuclease CAS6 2 (EC 3.1.-.-) | protein | 278 | 29% helix, 33% strand | Q97WV8 |
| J | CRISPR-associated endoribonuclease CAS6 2 (EC 3.1.-.-) | protein | 283 | 29% helix, 31% strand | Q97WV8 |
| L | CRISPR-associated endoribonuclease CAS6 2 (EC 3.1.-.-) | protein | 278 | 28% helix, 33% strand | Q97WV8 |
| N | CRISPR-associated endoribonuclease CAS6 2 (EC 3.1.-.-) | protein | 274 | 27% helix, 32% strand | Q97WV8 |
Pockets
20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 704 | 0.78 | 0.83 | 60 | empty |
| 2 | 681 | 0.77 | 0.82 | 97 | empty |
| 3 | 781 | 0.76 | 0.80 | 59 | empty |
| 4 | 71 | 0.73 | 0.97 | 28 | empty |
| 5 | 934 | 0.72 | 0.76 | 99 | empty |
Interfaces
27 interfaces between chains.
- B–C · 1549 Ų buried · 42 hydrogen bonds · protein-nucleic
- L–M · 1531 Ų buried · 51 hydrogen bonds · protein-nucleic
- J–K · 1519 Ų buried · 39 hydrogen bonds · protein-nucleic
- A–R · 1513 Ų buried · 52 hydrogen bonds · protein-nucleic
- F–G · 1510 Ų buried · 42 hydrogen bonds · protein-nucleic
Compared structures
- 4ILM · CRISPR RNA Processing endoribonuclease · the same entry in another collection · chain O against O, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q97WV8
- Elsewhere: RCSB PDB 4ILM · PDBe 4ILM · UniProt Q97WV8
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