MolNFT v1 · #9518 · protein

Crystal structure of transcription factor malt domain III

1HZ4 · Malt regulatory protein: “Crystal structure of transcription factor malt domain III”. X-ray diffraction, 2 ligands (BEZ, SO4), 1 pocket (best druggability 0.81). MolNFT v1 #9518 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 1HZ4
Type: protein
Length: 366 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Malt regulatory protein
UniProt: P06993
Ligands: BEZ, SO4
Pockets: 1 · best druggability 0.81

Structure

x-ray diffraction · 1 distinct chain · 80% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Malt regulatory protein	protein	366	80% helix, 0% strand	P06993

Ligands and binding sites

BEZ · Benzoic acid · ligand · chains A
SO4 · Sulfate ion · ion · 8 copies · chains A
GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	924	0.81	0.82	67	SO4, GOL

Compared structures

1HZ4 · Crystal structure of transcription factor malt domain III · the same entry in another collection · chain A against A, TM-score 1.00
P06993 · AlphaFold monomer V2.0 prediction for hth-type transcriptional regulator malt (P06993) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P06993
Elsewhere: RCSB PDB 1HZ4 · PDBe 1HZ4 · UniProt P06993

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