MolNFT v1 · #94982 · protein
Ubiquitin-like domain of human tubulin folding cofactor E - crystal from a
4ICU · Tubulin-specific chaperone E: “Ubiquitin-like domain of human tubulin folding cofactor E - crystal from a”. X-ray diffraction, 2 pockets (best druggability 0.76). MolNFT v1 #94982 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4ICU
- Type
- protein
- Length
- 336 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tubulin-specific chaperone E
- UniProt
- Q15813
- Pockets
- 2 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 21% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Tubulin-specific chaperone E | protein | 84 | 21% helix, 32% strand | Q15813 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 891 | 0.76 | 0.80 | 86 | empty |
| 2 | 56 | 0.28 | 0.75 | 13 | empty |
Interfaces
5 interfaces between chains.
- A–C · 581 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 427 Ų buried · 8 hydrogen bonds · protein-protein
- A–D · 358 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 323 Ų buried · 0 hydrogen bonds · protein-protein
- C–D · 116 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 4ICU · Ubiquitin-like domain of human tubulin folding cofactor E - crystal from A · the same entry in another collection · chain A against A, TM-score 1.00
- Q15813 · AlphaFold monomer V2.0 prediction for tubulin-specific chaperone E (Q15813) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15813
- Elsewhere: RCSB PDB 4ICU · PDBe 4ICU · UniProt Q15813
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