MolNFT v1 · #94854 · protein

Structure of the BSK8 kinase domain (semet labeled)

4I93 · Probable SERINE/THREONINE-protein kinase AT5G41260: “Structure of the BSK8 kinase domain (semet labeled)”. X-ray diffraction, 6 pockets (best druggability 0.82). MolNFT v1 #94854 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 4I93
Type: protein
Length: 572 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Probable SERINE/THREONINE-protein kinase AT5G41260
EC: 2.7.11.1
UniProt: Q9FHD7
Pockets: 6 · best druggability 0.82

Structure

x-ray diffraction · 2 distinct chains · 45% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Probable SERINE/THREONINE-protein kinase AT5G41260 (EC 2.7.11.1)	protein	289	46% helix, 12% strand	Q9FHD7
B	Probable SERINE/THREONINE-protein kinase AT5G41260 (EC 2.7.11.1)	protein	283	44% helix, 12% strand	Q9FHD7

Pockets

6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1101	0.82	0.83	102	empty
2	110	0.64	0.88	21	empty
3	173	0.63	0.85	42	empty
4	73	0.39	0.79	17	empty
5	58	0.37	0.79	15	empty

Interfaces

1 interface between chains.

A–B · 538 Å² buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 16 modified (engineered).

Compared structures

4I93 · Structure of the BSK8 kinase domain (SeMet labeled) · the same entry in another collection · chain A against A, TM-score 1.00
Q9FHD7 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase BSK8 (Q9FHD7) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9FHD7
Elsewhere: RCSB PDB 4I93 · PDBe 4I93 · UniProt Q9FHD7

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.