MolNFT v1 · #94760 · protein
Crystal structure of the K463A mutant of the rrm domain of RNA helicase hera from T. thermophilus
4I69 · Heat resistant RNA dependent ATPase: “Crystal structure of the K463A mutant of the rrm domain of RNA helicase hera from T. thermophilus”. X-ray diffraction, 1 ligand (CL), 2 pockets (best druggability 0.78). MolNFT v1 #94760 on…
- PDB
- 4I69
- Type
- protein
- Length
- 252 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heat resistant RNA dependent ATPase
- EC
- 3.6.4.13
- UniProt
- Q72GF3
- Ligands
- CL
- Pockets
- 2 · best druggability 0.78
Structure
x-ray diffraction · 3 distinct chains · 11% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Heat resistant RNA dependent ATPase (EC 3.6.4.13) | protein | 79 | 13% helix, 34% strand | Q72GF3 |
| B | Heat resistant RNA dependent ATPase (EC 3.6.4.13) | protein | 87 | 10% helix, 31% strand | Q72GF3 |
| C | Heat resistant RNA dependent ATPase (EC 3.6.4.13) | protein | 86 | 10% helix, 31% strand | Q72GF3 |
Ligands and binding sites
- CL · Chloride ion · ion · 4 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1014 | 0.78 | 0.80 | 79 | empty |
| 2 | 54 | 0.23 | 0.72 | 15 | empty |
Interfaces
3 interfaces between chains.
- A–B · 312 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 292 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 117 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4I69 · Crystal structure of the K463A mutant of the RRM domain of RNA helicase HERA from T.… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q72GF3
- Elsewhere: RCSB PDB 4I69 · PDBe 4I69 · UniProt Q72GF3
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.