MolNFT v1 · #94744 · protein
Crystal structure of yeast AP4A phosphorylase APA2
4I5T · 5',5'''-P-1,P-4-tetraphosphate phosphorylase 2: “Crystal structure of yeast AP4A phosphorylase APA2”. X-ray diffraction, 4 pockets (best druggability 0.69). MolNFT v1 #94744 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 4I5T
- Type
- protein
- Length
- 611 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 5',5'''-P-1,P-4-tetraphosphate phosphorylase 2
- EC
- 2.7.7.53
- UniProt
- P22108
- Pockets
- 4 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 28% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 5',5'''-P-1,P-4-tetraphosphate phosphorylase 2 (EC 2.7.7.53) | protein | 306 | 29% helix, 22% strand | P22108 |
| B | 5',5'''-P-1,P-4-tetraphosphate phosphorylase 2 (EC 2.7.7.53) | protein | 305 | 28% helix, 21% strand | P22108 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 590 | 0.69 | 0.78 | 64 | empty |
| 2 | 589 | 0.69 | 0.78 | 65 | empty |
| 3 | 451 | 0.66 | 0.78 | 47 | empty |
| 4 | 50 | 0.29 | 0.76 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 618 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22108
- Elsewhere: RCSB PDB 4I5T · PDBe 4I5T · UniProt P22108
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