MolNFT v1 · #94645 · protein
Crystal structure of the myosin chaperone unc-45 from C.ELEGANS in complex with a HSP70 peptide
4I2W · Protein unc-45: “Crystal structure of the myosin chaperone unc-45 from C.ELEGANS in complex with a HSP70 peptide”. X-ray diffraction, 9 pockets (best druggability 0.74). MolNFT v1 #94645 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4I2W
- Type
- protein
- Length
- 914 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein unc-45; Heat shock 70 kda protein a
- UniProt
- G5EG62, P09446
- Pockets
- 9 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 63% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein unc-45 | protein | 904 | 63% helix, 0% strand | G5EG62 |
| B | Heat shock 70 kda protein a | protein | 10 | 0% helix, 0% strand | P09446 |
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 552 | 0.74 | 0.82 | 60 | empty |
| 2 | 583 | 0.71 | 0.80 | 48 | empty |
| 3 | 129 | 0.63 | 0.86 | 29 | empty |
| 4 | 180 | 0.60 | 0.82 | 28 | empty |
| 5 | 147 | 0.48 | 0.78 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 457 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 25 modified (engineered).
Compared structures
- 4I2W · Crystal structure of the myosin chaperone UNC-45 from C.elegans in complex with a Hsp70… · the same entry in another collection · chain A against A, TM-score 1.00
- P09446 · AlphaFold monomer V2.0 prediction for heat shock protein HSP-1 (P09446) · a predicted model of the same protein · chain B against A, TM-score 0.36
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G5EG62
- Every structure of UniProt P09446
- Elsewhere: RCSB PDB 4I2W · PDBe 4I2W · UniProt G5EG62 · UniProt P09446
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