MolNFT v1 · #94606 · protein

Crystal structure of HBRAP1 N-bar domain

4I1Q · Bridging integrator 2: “Crystal structure of HBRAP1 N-bar domain”. X-ray diffraction, 3 pockets (best druggability 0.77). MolNFT v1 #94606 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4I1Q
Type: protein
Length: 398 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Bridging integrator 2
UniProt: Q9UBW5
Pockets: 3 · best druggability 0.77

Structure

x-ray diffraction · 2 distinct chains · 86% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Bridging integrator 2	protein	200	87% helix, 0% strand	Q9UBW5
B	Bridging integrator 2	protein	198	86% helix, 0% strand	Q9UBW5

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	93	0.77	0.97	17	empty
2	79	0.72	0.94	19	empty
3	67	0.70	0.96	17	empty

Interfaces

1 interface between chains.

A–B · 2204 Å² buried · 24 hydrogen bonds · protein-protein

Compared structures

4I1Q · Crystal Structure of hBRAP1 N-BAR domain · the same entry in another collection · chain A against A, TM-score 1.00
Q9UBW5 · AlphaFold monomer V2.0 prediction for bridging integrator 2 (Q9UBW5) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9UBW5
Elsewhere: RCSB PDB 4I1Q · PDBe 4I1Q · UniProt Q9UBW5

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