MolNFT v1 · #94535 · protein

Neutralizing antibody MAB#8 in complex with the epitope II of HCV E2 envelope protein

4HZL · Fab heavy chain: “Neutralizing antibody MAB#8 in complex with the epitope II of HCV E2 envelope protein”. X-ray diffraction, 10 pockets (best druggability 0.76). MolNFT v1 #94535 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 4HZL
Type: protein
Length: 894 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fab heavy chain; Fab light chain; E2 envelop protein
UniProt: F5BWY6
Pockets: 10 · best druggability 0.76

Structure

x-ray diffraction · 3 distinct chains · 9% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H, A	Fab heavy chain	protein	217	9% helix, 51% strand	—
L, B	Fab light chain	protein	217	7% helix, 51% strand	—
E, F	E2 envelop protein	protein	13	38% helix, 0% strand	F5BWY6

Pockets

10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	972	0.76	0.78	93	empty
2	921	0.75	0.79	79	empty
3	414	0.67	0.80	62	empty
4	267	0.59	0.79	34	empty
5	53	0.57	0.90	24	empty

Interfaces

10 interfaces between chains.

H–L · 1688 Å² buried · 16 hydrogen bonds · protein-protein
A–B · 1677 Å² buried · 15 hydrogen bonds · protein-protein
A–F · 618 Å² buried · 20 hydrogen bonds · protein-protein
H–E · 615 Å² buried · 17 hydrogen bonds · protein-protein
L–A · 531 Å² buried · 8 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 disulfide (disulfide).

Compared structures

4HZL · Neutralizing antibody mAb#8 in complex with the Epitope II of HCV E2 envelope protein · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt F5BWY6
Elsewhere: RCSB PDB 4HZL · PDBe 4HZL · UniProt F5BWY6

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.