MolNFT v1 · #94534 · protein
Crystal structure of free CRM1 (crystal form 2)
4HZK · CRM1 nuclear transport receptor: “Crystal structure of free CRM1 (crystal form 2)”. X-ray diffraction, 20 pockets (best druggability 0.77). MolNFT v1 #94534 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4HZK
- Type
- protein
- Length
- 2,064 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CRM1 nuclear transport receptor
- UniProt
- G0RZB7
- Pockets
- 20 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 75% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | CRM1 nuclear transport receptor | protein | 1033 | 75% helix, 1% strand | G0RZB7 |
| B | CRM1 nuclear transport receptor | protein | 1031 | 74% helix, 1% strand | G0RZB7 |
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 570 | 0.77 | 0.83 | 69 | empty |
| 2 | 937 | 0.77 | 0.79 | 85 | empty |
| 3 | 206 | 0.69 | 0.86 | 43 | empty |
| 4 | 204 | 0.66 | 0.84 | 32 | empty |
| 5 | 138 | 0.64 | 0.86 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 653 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 4HZK · Crystal structure of free CRM1 (crystal form 2) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0RZB7
- Elsewhere: RCSB PDB 4HZK · PDBe 4HZK · UniProt G0RZB7
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