MolNFT v1 · #94526 · protein

Crystal structure of the type VI semet effector-immunity complex TAE3- TAI3 from ralstonia pickettii

4HZB · Putative cytoplasmic protein: “Crystal structure of the type VI semet effector-immunity complex TAE3- TAI3 from ralstonia pickettii”. X-ray diffraction, 10 pockets (best druggability 0.78). MolNFT v1 #94526 on GenesisL1: 3D…

PDB: 4HZB
Type: protein
Length: 706 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Putative cytoplasmic protein; Putative periplasmic protein
UniProt: C6BHF2, C6BHF3
Pockets: 10 · best druggability 0.78

Structure

x-ray diffraction · 6 distinct chains · 34% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Putative cytoplasmic protein	protein	115	30% helix, 22% strand	C6BHF2
B	Putative periplasmic protein	protein	122	31% helix, 25% strand	C6BHF3
C	Putative periplasmic protein	protein	119	37% helix, 25% strand	C6BHF3
D	Putative cytoplasmic protein	protein	113	31% helix, 18% strand	C6BHF2
E	Putative periplasmic protein	protein	121	34% helix, 26% strand	C6BHF3
F	Putative periplasmic protein	protein	116	38% helix, 23% strand	C6BHF3

Pockets

10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	452	0.78	0.86	64	empty
2	362	0.75	0.86	41	empty
3	236	0.62	0.81	53	empty
4	215	0.62	0.82	52	empty
5	118	0.47	0.79	21	empty

Interfaces

10 interfaces between chains.

B–F · 1286 Å² buried · 23 hydrogen bonds · protein-protein
C–E · 1278 Å² buried · 20 hydrogen bonds · protein-protein
A–C · 984 Å² buried · 21 hydrogen bonds · protein-protein
D–F · 977 Å² buried · 22 hydrogen bonds · protein-protein
D–E · 804 Å² buried · 12 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 modified (engineered).

Compared structures

4HZB · Crystal structure of the type VI SeMet effector-immunity complex Tae3-Tai3 from Ralstonia… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt C6BHF2
Every structure of UniProt C6BHF3
Elsewhere: RCSB PDB 4HZB · PDBe 4HZB · UniProt C6BHF2 · UniProt C6BHF3

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.