MolNFT v1 · #94492 · protein
Structure of a presenilin family intramembrane aspartate protease in C2221 space group
4HYD · Putative uncharacterized protein: “Structure of a presenilin family intramembrane aspartate protease in C2221 space group”. X-ray diffraction, 10 pockets (best druggability 0.84). MolNFT v1 #94492 on GenesisL1: 3D structure, binding…
- PDB
- 4HYD
- Type
- protein
- Length
- 984 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative uncharacterized protein
- UniProt
- A3CWV0
- Pockets
- 10 · best druggability 0.84
Structure
x-ray diffraction · 1 distinct chain · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Putative uncharacterized protein | protein | 246 | 74% helix, 0% strand | A3CWV0 |
Pockets
10 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 924 | 0.84 | 0.85 | 90 | empty |
| 2 | 954 | 0.82 | 0.83 | 82 | empty |
| 3 | 1119 | 0.81 | 0.82 | 90 | empty |
| 4 | 1130 | 0.81 | 0.81 | 99 | empty |
| 5 | 253 | 0.61 | 0.80 | 28 | empty |
Interfaces
5 interfaces between chains.
- A–D · 941 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 855 Ų buried · 3 hydrogen bonds · protein-protein
- C–D · 794 Ų buried · 3 hydrogen bonds · protein-protein
- A–B · 777 Ų buried · 7 hydrogen bonds · protein-protein
- B–D · 18 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4HYD · Structure of a presenilin family intramembrane aspartate protease in C2221 space group · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A3CWV0
- Elsewhere: RCSB PDB 4HYD · PDBe 4HYD · UniProt A3CWV0
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