MolNFT v1 · #94491 · protein
Structure of a presenilin family intramembrane aspartate protease in P2 space group
4HYC · Putative uncharacterized protein: “Structure of a presenilin family intramembrane aspartate protease in P2 space group”. X-ray diffraction, 20 pockets (best druggability 0.81). MolNFT v1 #94491 on GenesisL1: 3D structure, binding…
- PDB
- 4HYC
- Type
- protein
- Length
- 1,968 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative uncharacterized protein
- UniProt
- A3CWV0
- Pockets
- 20 · best druggability 0.81
Structure
x-ray diffraction · 1 distinct chain · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H | Putative uncharacterized protein | protein | 246 | 74% helix, 0% strand | A3CWV0 |
Pockets
20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 873 | 0.81 | 0.83 | 76 | empty |
| 2 | 987 | 0.81 | 0.82 | 98 | empty |
| 3 | 944 | 0.81 | 0.82 | 80 | empty |
| 4 | 1015 | 0.81 | 0.81 | 100 | empty |
| 5 | 946 | 0.81 | 0.82 | 95 | empty |
Interfaces
12 interfaces between chains.
- E–F · 928 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 910 Ų buried · 3 hydrogen bonds · protein-protein
- A–D · 903 Ų buried · 4 hydrogen bonds · protein-protein
- G–H · 891 Ų buried · 5 hydrogen bonds · protein-protein
- F–G · 889 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 4HYC · Structure of a presenilin family intramembrane aspartate protease in P2 space group · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A3CWV0
- Elsewhere: RCSB PDB 4HYC · PDBe 4HYC · UniProt A3CWV0
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.