MolNFT v1 · #94406 · protein
Crystal structure of the T98E C-src-SH3 domain mutant in complex with the high affinity peptide APP12
4HVV · Proto-oncogene tyrosine-protein kinase src: “Crystal structure of the T98E C-src-SH3 domain mutant in complex with the high affinity peptide APP12”. X-ray diffraction, 2 ligands (ACE, SO4). MolNFT v1 #94406 on GenesisL1: 3D…
- PDB
- 4HVV
- Type
- protein
- Length
- 66 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proto-oncogene tyrosine-protein kinase src; Synthetic peptide acetyl-applpprnrp
- EC
- 2.7.10.2
- UniProt
- P00523
- Ligands
- ACE, SO4
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Proto-oncogene tyrosine-protein kinase src (EC 2.7.10.2) | protein | 56 | 5% helix, 46% strand | P00523 |
| B | Synthetic peptide acetyl-applpprnrp | protein | 10 | 0% helix, 0% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 501 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 covalent (covalent ligand).
Compared structures
- 4HVV · Crystal structure of the T98E c-Src-SH3 domain mutant in complex with the high affinity… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00523
- Elsewhere: RCSB PDB 4HVV · PDBe 4HVV · UniProt P00523
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