MolNFT v1 · #94383 · protein
Structure of mntr H77A mutant in apo- and mn-bound forms
4HV6 · Transcriptional regulator mntr: “Structure of mntr H77A mutant in apo- and mn-bound forms”. X-ray diffraction, 2 ligands (MN, MG), 2 pockets (best druggability 0.34). MolNFT v1 #94383 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4HV6
- Type
- protein
- Length
- 266 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcriptional regulator mntr
- UniProt
- P54512
- Ligands
- MN, MG
- Pockets
- 2 · best druggability 0.34
Structure
x-ray diffraction · 2 distinct chains · 74% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcriptional regulator mntr | protein | 133 | 76% helix, 5% strand | P54512 |
| B | Transcriptional regulator mntr | protein | 133 | 73% helix, 3% strand | P54512 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 73 | 0.34 | 0.76 | 14 | MN |
| 2 | 79 | 0.32 | 0.74 | 16 | MG |
Compared structures
- 4HV6 · Structure of MNTR H77A mutant in apo- and mn-bound forms · the same entry in another collection · chain A against A, TM-score 1.00
- P54512 · AlphaFold monomer V2.0 prediction for hth-type transcriptional regulator mntr (P54512) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P54512
- Elsewhere: RCSB PDB 4HV6 · PDBe 4HV6 · UniProt P54512
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