MolNFT v1 · #94317 · protein + RNA
Crystal structure of E COLI hfq bound to POLY(A) A7
4HT8 · Protein hfq: “Crystal structure of E COLI hfq bound to POLY(A) A7”. X-ray diffraction, 1 pocket (best druggability 0.71). MolNFT v1 #94317 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4HT8
- Type
- protein + RNA
- Length
- 376 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein hfq; RNA (5'-R(*AP*AP*AP*AP*AP*AP*A)-3')
- UniProt
- C6ECV6
- Pockets
- 1 · best druggability 0.71
Structure
x-ray diffraction · 3 distinct chains · 22% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | Protein hfq | protein | 61 | 23% helix, 49% strand | C6ECV6 |
| B, C, E, F | Protein hfq | protein | 60 | 22% helix, 50% strand | C6ECV6 |
| I, K | RNA (5'-R(*AP*AP*AP*AP*AP*AP*A)-3') | rna | 7 | — | — |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1019 | 0.71 | 0.75 | 69 | empty |
Interfaces
14 interfaces between chains.
- D–E · 685 Ų buried · 11 hydrogen bonds · protein-protein
- A–F · 666 Ų buried · 10 hydrogen bonds · protein-protein
- B–C · 660 Ų buried · 9 hydrogen bonds · protein-protein
- E–F · 658 Ų buried · 8 hydrogen bonds · protein-protein
- C–D · 649 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 4HT8 · Crystal structure of E coli Hfq bound to poly(A) A7 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C6ECV6
- Elsewhere: RCSB PDB 4HT8 · PDBe 4HT8 · UniProt C6ECV6
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