MolNFT v1 · #94288 · protein

Crystal structure of a cholesterol dependent cytolysin

4HSC · Streptolysin O: “Crystal structure of a cholesterol dependent cytolysin”. X-ray diffraction, 5 pockets (best druggability 0.62). MolNFT v1 #94288 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4HSC
Type: protein
Length: 469 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Streptolysin O
EC: 3.2.2.5
UniProt: P0DF97
Pockets: 5 · best druggability 0.62

Structure

x-ray diffraction · 1 distinct chain · 21% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
X	Streptolysin O (EC 3.2.2.5)	protein	469	21% helix, 42% strand	P0DF97

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	74	0.62	0.90	23	empty
2	56	0.48	0.85	18	empty
3	112	0.43	0.77	26	empty
4	58	0.32	0.76	14	empty
5	68	0.31	0.75	19	empty

Compared structures

4HSC · Crystal structure of a cholesterol dependent cytolysin · the same entry in another collection · chain X against X, TM-score 1.00
P0DF97 · AlphaFold monomer V2.0 prediction for streptolysin O (P0DF97) · a predicted model of the same protein · chain X against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0DF97
Elsewhere: RCSB PDB 4HSC · PDBe 4HSC · UniProt P0DF97

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