MolNFT v1 · #94207 · protein
PCGF1 ub fold (RAWUL)/BCOR pufd complex
4HPL · BCL-6 corepressor: “PCGF1 ub fold (RAWUL)/BCOR pufd complex”. X-ray diffraction, 2 pockets (best druggability 0.51). MolNFT v1 #94207 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4HPL
- Type
- protein
- Length
- 196 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- BCL-6 corepressor; Polycomb group ring finger protein 1
- UniProt
- Q6W2J9, Q9BSM1
- Pockets
- 2 · best druggability 0.51
Structure
x-ray diffraction · 2 distinct chains · 29% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | BCL-6 corepressor | protein | 113 | 32% helix, 28% strand | Q6W2J9 |
| B | Polycomb group ring finger protein 1 | protein | 83 | 25% helix, 33% strand | Q9BSM1 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 122 | 0.51 | 0.80 | 32 | empty |
| 2 | 99 | 0.38 | 0.75 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1566 Ų buried · 27 hydrogen bonds · protein-protein
Compared structures
- 4HPL · PCGF1 Ub fold (RAWUL)/BCOR PUFD Complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q9BSM1 · AlphaFold monomer V2.0 prediction for polycomb group ring finger protein 1 (Q9BSM1) · a predicted model of the same protein · chain B against A, TM-score 0.96
- Q6W2J9 · AlphaFold monomer V2.0 prediction for BCL-6 corepressor (Q6W2J9) · a predicted model of the same protein · chain A against A, TM-score 0.80
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6W2J9
- Every structure of UniProt Q9BSM1
- Elsewhere: RCSB PDB 4HPL · PDBe 4HPL · UniProt Q6W2J9 · UniProt Q9BSM1
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