MolNFT v1 · #94199 · protein
Crystal structure of nitrophorin 4 from rhodnius prolixus complexed with homocysteine at pH 7.4
4HPD · Nitrophorin-4: “Crystal structure of nitrophorin 4 from rhodnius prolixus complexed with homocysteine at pH 7.4”. X-ray diffraction, 2 ligands (HEM, HCS), 1 pocket (best druggability 0.77). MolNFT v1 #94199 on GenesisL1: 3D…
- PDB
- 4HPD
- Type
- protein
- Length
- 184 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nitrophorin-4
- UniProt
- Q94734
- Ligands
- HEM, HCS
- Pockets
- 1 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 13% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nitrophorin-4 | protein | 184 | 13% helix, 43% strand | Q94734 |
Ligands and binding sites
- HEM · Protoporphyrin IX containing Fe · ligand · chains A
- HCS · 2-amino-4-mercapto-butyric acid · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 535 | 0.77 | 0.84 | 49 | HEM, HCS |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4HPD · Crystal structure of Nitrophorin 4 from Rhodnius prolixus Complexed with homocysteine at… · the same entry in another collection · chain A against A, TM-score 1.00
- Q94734 · AlphaFold monomer V2.0 prediction for nitrophorin-4 (Q94734) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q94734
- Elsewhere: RCSB PDB 4HPD · PDBe 4HPD · UniProt Q94734
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