MolNFT v1 · #94198 · protein

Crystal structure of nitrophorin 4 from rhodnius prolixus complexed with cysteine at pH 7.4

4HPC · Nitrophorin-4: “Crystal structure of nitrophorin 4 from rhodnius prolixus complexed with cysteine at pH 7.4”. X-ray diffraction, 2 ligands (HEM, CYS), 1 pocket (best druggability 0.72). MolNFT v1 #94198 on GenesisL1: 3D structure…

PDB: 4HPC
Type: protein
Length: 179 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nitrophorin-4
UniProt: Q94734
Ligands: HEM, CYS
Pockets: 1 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 14% helix, 45% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nitrophorin-4	protein	179	14% helix, 45% strand	Q94734

Ligands and binding sites

HEM · Protoporphyrin IX containing Fe · ligand · chains A
CYS · Cysteine · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	381	0.72	0.83	38	HEM, CYS

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

4HPC · Crystal structure of Nitrophorin 4 from Rhodnius prolixus Complexed with Cysteine at pH… · the same entry in another collection · chain A against A, TM-score 1.00
Q94734 · AlphaFold monomer V2.0 prediction for nitrophorin-4 (Q94734) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q94734
Elsewhere: RCSB PDB 4HPC · PDBe 4HPC · UniProt Q94734

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