MolNFT v1 · #94171 · protein
Crystal structure of pas domain from the mouse EAG1 potassium channel
4HOI · Potassium voltage-gated channel subfamily H member 1: “Crystal structure of pas domain from the mouse EAG1 potassium channel”. X-ray diffraction, 1 ligand (SO4), 4 pockets (best druggability 0.49). MolNFT v1 #94171 on GenesisL1: 3D…
- PDB
- 4HOI
- Type
- protein
- Length
- 447 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Potassium voltage-gated channel subfamily H member 1
- UniProt
- Q60603
- Ligands
- SO4
- Pockets
- 4 · best druggability 0.49
Structure
x-ray diffraction · 3 distinct chains · 24% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Potassium voltage-gated channel subfamily H member 1 | protein | 113 | 23% helix, 36% strand | Q60603 |
| B | Potassium voltage-gated channel subfamily H member 1 | protein | 114 | 23% helix, 36% strand | Q60603 |
| C, D | Potassium voltage-gated channel subfamily H member 1 | protein | 110 | 26% helix, 37% strand | Q60603 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 6 copies · chains A, B, D, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 157 | 0.49 | 0.78 | 27 | SO4 |
| 2 | 209 | 0.48 | 0.75 | 29 | empty |
| 3 | 79 | 0.46 | 0.81 | 23 | empty |
| 4 | 63 | 0.29 | 0.74 | 16 | empty |
Interfaces
5 interfaces between chains.
- B–C · 784 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 496 Ų buried · 3 hydrogen bonds · protein-protein
- B–D · 294 Ų buried · 1 hydrogen bond · protein-protein
- A–D · 122 Ų buried · 2 hydrogen bonds · protein-protein
- C–D · 40 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4HOI · Crystal structure of PAS domain from the mouse EAG1 potassium channel · the same entry in another collection · chain A against A, TM-score 1.00
- Q60603 · AlphaFold monomer V2.0 prediction for potassium voltage-gated channel subfamily H member… · a predicted model of the same protein · chain C against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q60603
- Elsewhere: RCSB PDB 4HOI · PDBe 4HOI · UniProt Q60603
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