MolNFT v1 · #94164 · protein

The crystal structure of the zalpha domain from cyprinid herpes virus 3

4HOB · Putative uncharacterized protein: “The crystal structure of the zalpha domain from cyprinid herpes virus 3”. X-ray diffraction, 1 ligand (SO4), 2 pockets (best druggability 0.70). MolNFT v1 #94164 on GenesisL1: 3D structure, binding…

PDB: 4HOB
Type: protein
Length: 252 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Putative uncharacterized protein
UniProt: A4FTK7
Ligands: SO4
Pockets: 2 · best druggability 0.70

Structure

x-ray diffraction · 4 distinct chains · 52% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Putative uncharacterized protein	protein	62	53% helix, 11% strand	A4FTK7
B	Putative uncharacterized protein	protein	63	52% helix, 11% strand	A4FTK7
C	Putative uncharacterized protein	protein	67	49% helix, 10% strand	A4FTK7
D	Putative uncharacterized protein	protein	60	55% helix, 12% strand	A4FTK7

Ligands and binding sites

SO4 · Sulfate ion · ion · 9 copies · chains A, C, D, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	705	0.70	0.77	87	SO4
2	177	0.49	0.76	31	SO4

Interfaces

6 interfaces between chains.

A–B · 1483 Å² buried · 19 hydrogen bonds · protein-protein
C–D · 1245 Å² buried · 13 hydrogen bonds · protein-protein
B–D · 365 Å² buried · 4 hydrogen bonds · protein-protein
A–C · 359 Å² buried · 4 hydrogen bonds · protein-protein
B–C · 289 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

4HOB · The crystal structure of the Zalpha domain from Cyprinid Herpes virus 3 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A4FTK7
Elsewhere: RCSB PDB 4HOB · PDBe 4HOB · UniProt A4FTK7

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