MolNFT v1 · #94025 · protein
Crystal structure of drosophila melanogaster tryptophan 2,3- dioxygenase in complex with heme
4HKA · Tryptophan 2,3-dioxygenase: “Crystal structure of drosophila melanogaster tryptophan 2,3- dioxygenase in complex with heme”. X-ray diffraction, 1 ligand (HEM), 2 pockets (best druggability 0.79). MolNFT v1 #94025 on GenesisL1: 3D…
- PDB
- 4HKA
- Type
- protein
- Length
- 345 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tryptophan 2,3-dioxygenase
- EC
- 1.13.11.11
- UniProt
- P20351
- Ligands
- HEM
- Pockets
- 2 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 69% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tryptophan 2,3-dioxygenase (EC 1.13.11.11) | protein | 345 | 69% helix, 0% strand | P20351 |
Ligands and binding sites
- HEM · Protoporphyrin IX containing Fe · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 526 | 0.79 | 0.85 | 58 | HEM |
| 2 | 143 | 0.45 | 0.76 | 23 | empty |
Compared structures
- 4HKA · Crystal structure of Drosophila melanogaster tryptophan 2,3-dioxygenase in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
- P20351 · AlphaFold monomer V2.0 prediction for tryptophan 2,3-dioxygenase (P20351) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P20351
- Elsewhere: RCSB PDB 4HKA · PDBe 4HKA · UniProt P20351
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.