MolNFT v1 · #93988 · protein + DNA

Crystal structure of schizosaccharomyces pombe POT1PC bound to ssdna (ggttacgct)

4HJ8 · Protection of telomeres protein 1: “Crystal structure of schizosaccharomyces pombe POT1PC bound to ssdna (ggttacgct)”. X-ray diffraction, 1 pocket (best druggability 0.44). MolNFT v1 #93988 on GenesisL1: 3D structure, binding sites…

PDB: 4HJ8
Type: protein + DNA
Length: 147 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protection of telomeres protein 1; DNA (5'-D(*GP*GP*TP*TP*AP*CP*GP*CP*T)-3')
UniProt: O13988
Pockets: 1 · best druggability 0.44

Structure

x-ray diffraction · 2 distinct chains · 17% helix, 36% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protection of telomeres protein 1	protein	138	17% helix, 36% strand	O13988
B	DNA (5'-D(GPGPTPTPAPCPGPCP*T)-3')	dna	9	—	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	86	0.44	0.81	13	empty

Interfaces

1 interface between chains.

A–B · 1053 Å² buried · 29 hydrogen bonds · protein-nucleic

Compared structures

4HJ8 · Crystal Structure of Schizosaccharomyces pombe Pot1pC bound to ssDNA (GGTTACGCT) · the same entry in another collection · chain A against A, TM-score 1.00
O13988 · AlphaFold monomer V2.0 prediction for protection of telomeres protein 1 (O13988) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O13988
Elsewhere: RCSB PDB 4HJ8 · PDBe 4HJ8 · UniProt O13988

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