MolNFT v1 · #93964 · protein + DNA
Crystal structure of schizosaccharomyces pombe POT1PC bound to ssdna (ggttacggt)
4HIK · Protection of telomeres protein 1: “Crystal structure of schizosaccharomyces pombe POT1PC bound to ssdna (ggttacggt)”. X-ray diffraction, 2 pockets (best druggability 0.45). MolNFT v1 #93964 on GenesisL1: 3D structure, binding sites…
- PDB
- 4HIK
- Type
- protein + DNA
- Length
- 147 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protection of telomeres protein 1; DNA (5'-D(*GP*GP*TP*TP*AP*CP*GP*GP*T)-3')
- UniProt
- O13988
- Pockets
- 2 · best druggability 0.45
Structure
x-ray diffraction · 2 distinct chains · 17% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protection of telomeres protein 1 | protein | 138 | 17% helix, 34% strand | O13988 |
| B | DNA (5'-D(*GP*GP*TP*TP*AP*CP*GP*GP*T)-3') | dna | 9 | — | — |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 95 | 0.45 | 0.80 | 14 | empty |
| 2 | 74 | 0.41 | 0.79 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 1061 Ų buried · 27 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 3 modified (engineered).
Compared structures
- 4HIK · Crystal Structure of Schizosaccharomyces pombe Pot1pC bound to ssDNA (GGTTACGGT) · the same entry in another collection · chain A against A, TM-score 1.00
- O13988 · AlphaFold monomer V2.0 prediction for protection of telomeres protein 1 (O13988) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O13988
- Elsewhere: RCSB PDB 4HIK · PDBe 4HIK · UniProt O13988
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