MolNFT v1 · #93925 · protein

Quinolinate synthase from pyrococcus furiosus

4HHE · Quinolinate synthase a: “Quinolinate synthase from pyrococcus furiosus”. X-ray diffraction, 1 ligand (CL), 1 pocket (best druggability 0.59). MolNFT v1 #93925 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4HHE
Type: protein
Length: 297 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Quinolinate synthase a
EC: 2.5.1.72
UniProt: Q8TZL3
Ligands: CL
Pockets: 1 · best druggability 0.59

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Quinolinate synthase a (EC 2.5.1.72)	protein	297	43% helix, 15% strand	Q8TZL3

Ligands and binding sites

CL · Chloride ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	453	0.59	0.75	69	CL

Compared structures

4HHE · Quinolinate synthase from Pyrococcus furiosus · the same entry in another collection · chain A against A, TM-score 1.00
Q8TZL3 · AlphaFold monomer V2.0 prediction for quinolinate synthase a (Q8TZL3) · a predicted model of the same protein · chain A against A, TM-score 0.66

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8TZL3
Elsewhere: RCSB PDB 4HHE · PDBe 4HHE · UniProt Q8TZL3

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