MolNFT v1 · #93870 · protein
Biogenic amine-binding protein selenomethionine derivative
4HFO: “Biogenic amine-binding protein selenomethionine derivative”. X-ray diffraction, 20 pockets (best druggability 0.75). MolNFT v1 #93870 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4HFO
- Type
- protein
- Length
- 1,552 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Biogenic amine-binding protein
- UniProt
- Q86PT9
- Pockets
- 20 · best druggability 0.75
Structure
x-ray diffraction · 3 distinct chains · 21% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, I | Biogenic amine-binding protein | protein | 195 | 21% helix, 42% strand | Q86PT9 |
| B, D, J, L | Biogenic amine-binding protein | protein | 194 | 21% helix, 40% strand | Q86PT9 |
| C, K | Biogenic amine-binding protein | protein | 193 | 21% helix, 40% strand | Q86PT9 |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 465 | 0.75 | 0.84 | 62 | empty |
| 2 | 618 | 0.75 | 0.81 | 76 | empty |
| 3 | 287 | 0.68 | 0.83 | 38 | empty |
| 4 | 194 | 0.67 | 0.85 | 31 | empty |
| 5 | 178 | 0.67 | 0.86 | 30 | empty |
Interfaces
14 interfaces between chains.
- K–L · 688 Ų buried · 20 hydrogen bonds · protein-protein
- C–D · 676 Ų buried · 16 hydrogen bonds · protein-protein
- B–D · 675 Ų buried · 10 hydrogen bonds · protein-protein
- J–L · 646 Ų buried · 9 hydrogen bonds · protein-protein
- J–K · 308 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 disulfide, 16 modified (disulfide, engineered).
Compared structures
- 4HFO · Biogenic amine-binding protein selenomethionine derivative · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q86PT9
- Elsewhere: RCSB PDB 4HFO · PDBe 4HFO · UniProt Q86PT9
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.