MolNFT v1 · #93791 · protein

Crystal structure of tyrosinase from bacillus megaterium V218F mutant soaked in CUSO4

4HD6: “Crystal structure of tyrosinase from bacillus megaterium V218F mutant soaked in CUSO4”. X-ray diffraction, 1 ligand (CU), 2 pockets (best druggability 0.75). MolNFT v1 #93791 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 4HD6
Type: protein
Length: 573 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosinase
EC: 1.14.18.1
UniProt: B2ZB02
Ligands: CU
Pockets: 2 · best druggability 0.75

Structure

x-ray diffraction · 2 distinct chains · 42% helix, 6% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tyrosinase (EC 1.14.18.1)	protein	287	42% helix, 6% strand	B2ZB02
B	Tyrosinase (EC 1.14.18.1)	protein	286	42% helix, 5% strand	B2ZB02

Ligands and binding sites

CU · Copper (II) ion · metal · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	389	0.75	0.85	64	empty
2	51	0.33	0.78	16	empty

Interfaces

1 interface between chains.

A–B · 1137 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

4HD6 · Crystal Structure of Tyrosinase from Bacillus megaterium V218F mutant soaked in CuSO4 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B2ZB02
Elsewhere: RCSB PDB 4HD6 · PDBe 4HD6 · UniProt B2ZB02

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.