MolNFT v1 · #93766 · protein
Crystal structure of the telomeric saccharomyces cerevisiae CDC13 OB2 domain
4HCE · Cell division control protein 13: “Crystal structure of the telomeric saccharomyces cerevisiae CDC13 OB2 domain”. X-ray diffraction, 5 pockets (best druggability 0.80). MolNFT v1 #93766 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4HCE
- Type
- protein
- Length
- 259 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cell division control protein 13
- UniProt
- P32797
- Pockets
- 5 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 21% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cell division control protein 13 | protein | 129 | 22% helix, 36% strand | P32797 |
| B | Cell division control protein 13 | protein | 130 | 21% helix, 35% strand | P32797 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 267 | 0.80 | 0.92 | 41 | empty |
| 2 | 128 | 0.43 | 0.76 | 16 | empty |
| 3 | 64 | 0.35 | 0.78 | 16 | empty |
| 4 | 73 | 0.33 | 0.75 | 18 | empty |
| 5 | 67 | 0.30 | 0.74 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1445 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 4HCE · Crystal structure of the telomeric Saccharomyces cerevisiae Cdc13 OB2 domain · the same entry in another collection · chain A against A, TM-score 1.00
- P32797 · AlphaFold monomer V2.0 prediction for cell division control protein 13 (P32797) · a predicted model of the same protein · chain A against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32797
- Elsewhere: RCSB PDB 4HCE · PDBe 4HCE · UniProt P32797
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