MolNFT v1 · #93690 · protein
Structural insights into the reduction mechanism of saccharomyces cerevisia riboflavin biosynthesis reductase RIB7
4HA7 · 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate…: “Structural insights into the reduction mechanism of saccharomyces cerevisia riboflavin biosynthesis reductase…”. X-ray diffraction, 7 pockets (best druggability 0.58).…
- PDB
- 4HA7
- Type
- protein
- Length
- 426 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase
- EC
- 1.1.1.302
- UniProt
- P33312
- Pockets
- 7 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 22% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase (EC 1.1.1.302) | protein | 221 | 22% helix, 28% strand | P33312 |
| B | 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase (EC 1.1.1.302) | protein | 205 | 22% helix, 28% strand | P33312 |
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 366 | 0.58 | 0.76 | 39 | empty |
| 2 | 118 | 0.40 | 0.75 | 19 | empty |
| 3 | 73 | 0.39 | 0.78 | 18 | empty |
| 4 | 98 | 0.38 | 0.76 | 21 | empty |
| 5 | 75 | 0.29 | 0.73 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 1338 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 4HA7 · Structural insights into the reduction mechanism of Saccharomyces cerevisia Riboflavin… · the same entry in another collection · chain A against A, TM-score 1.00
- P33312 · AlphaFold monomer V2.0 prediction for 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone… · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P33312
- Elsewhere: RCSB PDB 4HA7 · PDBe 4HA7 · UniProt P33312
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.