MolNFT v1 · #93603 · protein

The X-ray crystal structure of the trichoderma harzianum endoglucanase 3 from family GH12

4H7M · Endo-1,4-beta-glucanase: “The X-ray crystal structure of the trichoderma harzianum endoglucanase 3 from family GH12”. X-ray diffraction, 4 pockets (best druggability 0.54). MolNFT v1 #93603 on GenesisL1: 3D structure, binding sites…

PDB: 4H7M
Type: protein
Length: 451 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Endo-1,4-beta-glucanase
EC: 3.2.1.4
UniProt: I3RY46
Pockets: 4 · best druggability 0.54

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 55% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Endo-1,4-beta-glucanase (EC 3.2.1.4)	protein	226	7% helix, 55% strand	I3RY46
B	Endo-1,4-beta-glucanase (EC 3.2.1.4)	protein	225	8% helix, 54% strand	I3RY46

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	216	0.54	0.78	28	empty
2	186	0.47	0.75	27	empty
3	181	0.46	0.75	34	empty
4	152	0.45	0.76	37	empty

Interfaces

1 interface between chains.

A–B · 386 Å² buried · 10 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

4H7M · The X-ray Crystal Structure of the Trichoderma harzianum Endoglucanase 3 from family GH12 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt I3RY46
Elsewhere: RCSB PDB 4H7M · PDBe 4H7M · UniProt I3RY46

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